Positive structural fetal anomalies

Gestational age (the earliest in case of repeated US exams)—categories

P

First trimester (8 - 14 weeks)

Second trimester

Third trimester

N (%)

N (%)

N (%)

(Total n = 487)

(Total n = 1096)

(Total n = 514)

Abdominal wall anomalies

1 (0.2)

6 (0.5)

1 (0.2)

0.44 [NS]

Abnormalities of brain

4 (0.8)

31 (2.8)

18 (3.5)

0.017

Extremities abnormalities

3 (0.6)

41 (3.7)

17 (3.3)

0.002

Face anomalies

0 (0)

4 (0.4)

4 (0.8)

0.14 [NS]

GIT anomalies

4 (0.8)

19 (1.7)

22 (4.3)

<0.001

Head anomalies

3 (0.6)

14 (1.3)

5 (1)

0.48 [NS]

Heart anomalies

3 (0.6)

18 (1.6)

12 (2.3)

0.09 [NS]

Abnormalities of neck and skin

4 (0.8)

10 (0.9)

3 (0.6)

0.79 [NS]

Spine anomalies

3 (0.6)

10 (0.9)

6 (1.2)

0.65 [NS]

Thorax anomalies

6 (1.2)

33 (3)

15 (2.9)

0.1 [NS]

Urinary tract abnormalities

2 (0.4)

35 (3.2)

19 (3.7)

0.002

Abnormal genitalia

1 (0.2)

0 (0)

2 (0.4)

0.14 [NS]

Any positive visible fetal abnormality detected by US

14 (2.9)

104 (9.5)

60 (11.7)

<0.001